Generic Name: Metronidazole 800mg
Manufacturer/Distributor: Beximco Pharmaceuticals Ltd.
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Indications
Filmet DS 800 is an antibiotic that aids your body's ability to fight infections caused by bacteria and parasites. It is employed in the treatment of infections of the liver, stomach, intestines, vagina, brain, heart, lungs, bones, and skin. Filmet DS 800 aids in the prevention of infection following surgery. It's also used to treat tooth infections, leg ulcers, and pressure sores. This medication is best taken after a meal. To get the most out of it, take it at the same time every day. The amount prescribed will depend on what you are being treated for and how severe your condition is, but you must take this antibiotic exactly as directed by your doctor.
Pharmacology
Metronidazole belongs to the imidazole class of antibacterial medications and is classified as an antiprotozoal specialist. Anaerobes reduce the 5-nitro gather of Metronidazole metabolically. Considerations have shown that the reduced shape of this sedate is interatomic with DNA and provides Metronidazole's bactericidal activity.
Dosage & Administration
Suspension and Tablet:
Trichomoniasis (Adults and Children Over the Age of 10)-
Children's Trichomoniasis-
Adults and children over the age of ten who have intestinal amoebiasis
For 5 days, take 800 mg tid.
Amoebiasis of the intestine (Children)-
For 5-10 days, take 400-800 mg tid.
For three days, take 200 mg twice a day. Children with acute ulcerative gingivitis-
Suppository:
Anaerobic Infections –
Vaginal Gel:
IV Infusion:
Metronidazole intravenous infusion does not require dilution and should not be mixed with any other medications before administration.
Interaction
Disulfiram: Patients who were taking metronidazole and disulfiram at the same time experienced insane reactions. Alcohol: Due to the possibility of a disulfiram-like (Antabuse effect) response (flushing, heaving, tachycardia), alcoholic beverages and drugs containing liquor should be avoided during treatment and for at least one day after. Verbal anticoagulant treatment (warfarin sort): Reduced hepatic catabolism causes anticoagulant potentiation and increased hemorrhagic risk. In the case of co-administration, prothrombin time should be checked more frequently and anticoagulant treatment should be balanced alongside metronidazole treatment. Metronidazole can increase lithium levels in the blood. Cyclosporine: When co-administration is required, serum cyclosporine and serum creatinine should be closely monitored. Phenytoin or phenobarbital: metronidazole's extended end resulted in lower plasma levels.
Contraindications
Metronidazole is contraindicated in patients with a history of extreme touchiness to Metronidazole or other Nitroimidazole subordinates.
Side Effect
Pregnancy & Lactation
US FDA Pregnancy Category of Metronidazole is B. There are, be that as it may, no satisfactory and well-controlled considerations in pregnant ladies. Since creature propagation ponders are not continuously prescient of human reaction, this medication ought to be utilized amid pregnancy as it were in the event that clearly required. Metronidazole has appeared to be excreted in the human drain. So, caution ought to be worked out when Metronidazole is managed by a nursing lady.
Precautions & Warnings
If metronidazole must be administered for a longer period than recommended, hematological tests, particularly leucocyte count, should be performed on a regular basis, and patients should be monitored for adverse reactions, for example, peripheral or central neuropathy (such as paresthesia, ataxia, tipsiness, convulsive seizures). Metronidazole should be used with caution in patients with hepatic encephalopathy. Patients should be warned that metronidazole can make it difficult to pee. Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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